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The (+/-)-trans- or cis-4(5)-(5-aminomethyltetrahydrofuranyl)imidazole [1 and 2] were synthesized by the Mitsunobu cyclization, starting from L-glutamic acid.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Synthesis of (.+-.)-trans- or cis-(5-Aminomethyltetrahydrofuranyl)imidazole by Mitsunobu Cyclization: Synthetic Studies toward Novel Histamine H3 or H4-Ligands.