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Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.

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Cytotoxic and Apoptosis-Inducing &lt;i&gt;ent&lt;/i&gt;-Kaurane-Type Diterpenoids from the Japanese Liverwort &lt;i&gt;Jungermannia truncata&lt;/i&gt; N&lt;small&gt;EES&lt;/small&gt;