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In a search for novel atypical antipsychotics, the synthesis of new hexahydrocarbazoles and spiro indoles N-substituted with a 3-(dimethylamino)propyl chain is described, together with the results of an in vitro evaluation of their affinities for D2 and 5-HT2A receptors.

New Hexahydrocarbazoles and Spiro Indoles, and Their Affinity for D2 Dopamine and 5-HT2A Serotonin Receptors.