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Bisnetropsin-linked hydroxamic acids (BNHA) were shown to cleave DNA stands at a single residue with a preferred binding orientation in the presence of ferrous ion. In contrast, the corresponding cerium (III) complexes cleaved DNA with low sequence specificity.

Sequence Specificity of DNA Cleavage by Bisnetropsin-Linked Hydroxamic Acid-Metal Complexes: Highly Specific Cleavage by Ferrous Complexes.