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The rapid drug release from a double-compressed tablet containing theophylline with the water-soluble polymer polymethacrylic acid (PMAA) or polyacrylamide (PAAm) used as a wall material can be suppressed by argon plasma irradiation and changed into the slow release due to a decrease in the solubility of water-soluble polymers used as the outer layer. This report is the first to deal with an attempt to control the release of drugs by controlling polymer solubility, and to fabricate a completely soluble controlled release type of drug delivery system (DDS) making use of plasma processing.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. VI. Controlled Release of Theophylline from Plasma-Irradiated Double-Compressed Tablet Composed of Water-Soluble Polymers as a Wall Material.