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Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Tannins and Related Polyphenols from Elaeagnaceous Plants. Part 2. New Hydrolyzable Tannins, Shephagenins A and B, from Shepherdia argentea as HIV-1 Reverse Transcriptase Inhibitors.