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The reaction of dihydroxo(1R,2R-cyclohexanediamine)platinum(II) with 2,4-dioxopentanoic acid gave a water-soluble complex, (1R,2R-cyclohexanediamine-N,N')[2-hydroxy-4-oxo-2-pentenoato (2-)-O2] platinum(II). The structure of the complex was determined by X-ray crystal analysis. The data indicated a chelation of the acetylacetonato part of 2,4-dioxo-pentanoic acid to platinum(II). The complex showed moderate antitumor activity against murine leukemia L1210 in mice (T/C = 195% at a dose of 200 mg/kg) and high activity against cisplatin-resistant L1210 leukemia (T/C = 275% at a dose of 25 mg/kg).

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Synthesis, Structure and Antitumor Activity of a New Water-Soluble Platinum Complex, (1R, 2R-Cyclohexanediamine-N,N')(2-hydroxy-4-oxo-2-pentenoato(2-)-O2)platinum(II).