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The saponin fraction prepared from the methanolic extract of the underground parts of Agapanthus inapertus was found to exhibit inhibitory activity on cAMP phosphodiesterase (55.2%) at a concentration of 100 micrograms/ml. From this fraction, four new steroidal saponins, designated as agapanthussaponin A (1), B (2), C (3) and D (4), were isolated as the active principles, along with an inactive new furostanol saponin (5). The structures of 1-5 were determined by spectroscopic data and hydrolysis. The IC50 of 1-4 on cAMP phosphodiesterase were 0.7, 1.2, 1.1 and 2.0 (x 10(-5) M), respectively, which are more potent than that of papaverine (IC50 3.0 x 10(-5) M).

Agapanthussaponins A-D, New Potent cAMP Phosphodiesterase Inhibitors from the Underground Parts of Agapanthus inapertus.