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A controlled-release tablet can be obtained by oxygen plasma irradiation on the outer layer double-compressed tablets prepared from theophylline as a core material and polycarbonate derived from bisphenol A (PC) as a single wall material, making this possible that PC is of intramolecular bifunctionality, crosslinkable phenyl group and degradable carbonate group as an effect of plasma irradiation. It was shown that the dissolution profiles can be varied so as to cause release of theophylline at different rates, depending on the set of conditions chosen for tablet manufacturing as well as plasma operational conditions.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

A New Drug Delivery System(DDS) Development Using Plasma-Irradiated Pharamaceutical Aids. IV. Controlled Release of Theophylline from Plasma-Irradiated Double-Compressed Tablet Composed of Polycarbonate as a Single Wall Material.