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The synthesis of a new series of dihydropyridines containing a nitrooxy moiety at the 3-ester position is described. The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.

Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Derivatives Containing a Nitrooxy Moiety at the 3-Ester Position.