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A series of substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids 13 and 1,3-dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic acids 14 were synthesized and evaluated for diuretic and uricosuric activities in rats. Most of the benzisoxazole derivatives 13 and 14 showed potent diuretic activities. Moderate uricosuric activities were also found in 14a, 14b, and 14f.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Studies on Uricosuric Diuretics. III. Substituted 1,3-Dioxolo(4,5-f)-1,2-benzisoxazole-6-carboxylic Acids and 1,3-Dioxolo(4,5-g)-1,2-benzisoxazole-7-carboxylic Acids.