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Hybrids of a fibronectin-related tripeptide (Arg-Gly-Asp) and amino-poly(ethylene glycol) were prepared and their inhibitory effect on experimental metastasis in mice was examined. The hybrids exhibited a potent inhibitory effect on the metastasis of B16 melanoma BL6.

Preparation of (Mrg-Gly-Asp)-(amino-poly(ethylene glycol)) hybrids and their inhibitory effect on experimental metastasis.