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The hot water extracts of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas, were found to have potent inhibitory activity towards lens aldose reductase (AR). Ellagic acid (4) was isolated from C. morifolium and I. batatas, isoscutellarein (7) from B. orellana and 3,5-dicaffeoylquinic acid (10) from I. batatas, respectively, as potent inhibitors.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Studies on Aldose Reductase Inhibitors from Natural Products. IV. Constituents and Aldose Reductase Inhibitory Effect of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas.