English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The alkylation of adenosine-3',5'-cyclic phosphate (cAMP, 1) with alkyl bromides was investigated and various new alkylated cAMP derivatives, N6,N6,2'-O-trialkyl cAMPs (2), N6,2'-O-dialkyl cAMPs (3) and 2'-O-alkyl cAMPs (4), were prepared by a one step reaction without the introduction of a protecting group into 1. Compounds (2) were synthesized from 1 by treatment with alkyl bromides in the presence of NaH or potassium tert-butoxide in dimethyl sulfoxide. Compounds (3) were also synthesized from 1 under conditions similar to those of the synthesis of 2 except for the use of MeONa as a base. Compounds (4) were prepared from 1 by treatment with alkyl bromides in the presence of 18-crown-6 in dioxane-aqueous KOH solution. N6,2'-O-Dibenzyl cAMP (3e) was obtained from 1 by the same method as the preparation of 4. These new alkylated derivatives were evaluated for cardiotonic activity in vitro. Some of them showed weak positive inotropic effects and strong negative chronotropic effects. Thus, the presence of the 2'-hydroxyl group seemed to be essential for the appearance of potent positive inotropic activity caused by cAMP derivatives.

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Studies on the synthesis of compounds related to adenosine-3',5'-cyclic phosphate. VI. Synthesis and cardiac effects of N6,N6,2'-O-trialkyl-, N6,2'-O-dialkyl-, and 2'-O-alkyladenosine-3'm5'-cyclic phosphates.