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The present study was undertaken to investigate the changes of plasma and urinary levels of guanidinoacetic acid (GAA) in relation to the alteration of renal activity of glycine amidinotransferase (GAT) in the acute stage of renal failure. Rats received cephaloridine at doses of 0 (control), 100 and 1000 mg/kg body weight. The 100 mg/kg group showed rises in the urinary excretion of GAA from the 2nd to the 4th day, but did not show any changes in the other items determined. The urinary excretion of GAA in the 1000 mg/kg group showed a rise on the 1st day, and a fall on the 3rd day. The renal arginine in the group fell from days 1 to 4. The renal activity of GAT in the group fell from day 2, reached the lowest level on day 3, and reverted to the control level after day 5. These results suggest that the rise in the urinary excretion of GAA on the 1st day was ascribable to an inhibitory effect of cephaloridine on renal reabsorption of GAA, and that the fall in its urinary excretion on the 3rd day was ascribable to the suppression in the renal GAA formation system including GAT, arginine and so on.

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Interrelation of urinary and plasma levels of guanidinoacetic acid with alteration in renal activity of glycine amidinotransferase in acute renal failure rats.