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The ether-soluble fraction of MeOH extract from the leaves of Cryptomeria japonica D. DON showed an anti-inflammatory effect when topically applied to rats and an inhibitory effect on histamine-induced ileum contraction. The active component was isolated and identified as ciscommunic acid (1). Two new diterpenoids were also isolated along with two known compounds and were determined to be imbricataloic acid dimethyl acetal (5) and (E)-13-hydroxylabda-8 (17), 11, 14-trien-19-oic acid, obtained as the methyl ester (6m), by chemical and spectroscopic methods.

Anti-inflammatory constituents of topically applied crude drugs. II. Constituents and anti-inflammatory effect of Cryptomeria japonica D. DON.