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Trimethylsilyl bromide (TMSBr) in trifluoroacetic acid (TFA) was found to have the ability to cleave benzyl-type protecting groups, i.e., benzyloxycarbonyl (Z), benzyl (O-Bzl) and p-methoxybenzyl (S-MBzl). The reaction was best accelerated by addition of thioanisole, compared with other soft nucleophiles so far examined. The rate of the cleavage reaction with TMSBr/TFA was judged to be somewhat slower than that with trimethylsilyl trifluoromethanesulfonate/TFA. However, TMSBr/TFA reduced Met(O) efficiently and gave almost no side reaction of Asp (succinimide formation). This deprotecting procedure was applied to the synthesis of human gastrin-releasing peptide.

Studies on peptides. CLV. Evaluation of trimethylsilyl bromide as a hard-acid deprotecting reagent in peptide synthesis.