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Sclerotinia sclerotiorum IFO 9395 strain produces "sclerotia" on agar media. The immunomodulating activities of the non-dialyzable fraction of hot water extract of sclerotia (TSHW) grown on six kinds of agar media (i.e., malt (M), potato-sucrose (PS), potato-dextrose (P), YpSs (Y), Leonian-yeast extract (L) and malt-yeast extract (MY)) were comparatively studied. The sclerotial formation was strongly affected by the composition of the media. The yield was the highest on PS agar (26.8 g as average dry weight of sclerotia per 100 agar plates), and the lowest on MY agar. However, the yield, composition (protein ca. 30%, carbohydrate ca. 60%, phosphate (•ƒ0.4%)), carbohydrate components (glucose and mannose in a molar ratio of 1.0: ca. 0.5) and amino acid composition of TSHW were similar on all the media. The results of methylation analysis indicated that all the TSHW preparations possessed quite similar branched ƒÀ-1,3-glucan structures. These TSHW preparations showed various immunomodulating effects (mitogenic, polyclonal B-cell activating (PBA), reticuloendothelial system (RES)-activating, and antitumor activities). Antitumor and RES activation activities of TSHW were quite similar regardless of the difference of culture media, while mitogenic and PBA activities varied somewhat. These results suggest that the sclerotia contained immunomodulating material(s), the production of which was affected, in part, by the composition of the culture media.

Study on the immunomodulating activities of hot water extracts of sclerotia of Sclerotinia sclerotiorum IFO 9395 strain cultured on several media.