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A new colorimetric method for the determination of 4-hydroxylaminobenzenesulfonamide was examined. It is said that this compound is a hapten inducing drug allergy due to sulfanilamide and is formed in vivo and in vitro.4-Hydroxylaminobenzenesulfonamide produced a red violet complex having λ max at 515mμ in aqueous solution, when it was reacted with sodium pentacyanoammineferroate. Therefore, the estimation of 4-hydroxylaminobenzenesulfonamide using this reagent was attempted in biological materials.The effects of variation of times, pH and reagent concentration on the color development have been determined. This method was highly selective for the compound among the large amount of sulfanilamide and its metabolites. All the procedure was carried out in phosphate buffer solution at room temperature. The precision of the method which was obtained by performing 20 analyses on urine, was 50.02±1.76μg (mean±SD).

chemical and pharmaceutical bulletin/chemical and pharmaceutical bulletin

Studies on the Mechanism of Drug Allergy to Sulfanilamides. I. A Colorimetric Method for the Determination of 4-Hydroxylaminobenzenesulfonamide in Biological Materials with Sodium Pentacyanoammineferroate