English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Both the reactions proceeded successfully by means of catalytic hydrogenation of the compounds, I and II, in ammoniacal formamide over Raney nickel catalyst under high hydrogen pressure. Representative conditions are shown in the following: 150-155•‹, 4hr, 80 kg/cm2 of initial hydrogen pressure, and content of ammonia in formamide is about 7%. Under these conditions 60-70% yields of practically pure crystals of hypoxanthine and adenine, which were calculated from the starting I and II, were obtained. Because of ease of preparations of the compounds I and II, the above reactions appeared to provide convenient synthetic methods for preparations of hypoxanthine and adenine which may find_ an increasing demand in chemical industry. Instead of the compound, I, ethyl 2-cyano-2-phenylazo-acetate and 2-cyano-2-nitrosoacetamide can be also applied to the above method giving hypoxanthine, but the yields were lower. On survey of other chemical reduction method sodium dithionite and sodium sulfite were also effective for the conversion of I into hypoxanthine by means of adding these reagents to formamide solution containing I and ammonium chloride at the elevated temperature. However, yields of hypoxanthine were much lower than that in the above method. When N-alkyl substituted compound, i.e. N-alkyl-2-cyano-2-phenylazo-acetamide, was used instead of I, there was obtained 1-alkyl-substituted hypoxanthine. This was exemplified in the formations of 1-methyland 1-benzylhypoxanthine, which were obtained in 64% and 62% yield, respectively, and exhibited ultraviolet (UV) absorptions characteristic of 1-alkyl-substituted hypoxanthine.

Facile Syntheses of Hypoxanthine and Adenine