English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Cimetidine, a histamine H2 receptor antagonist, is known to have some effects on central nervous system, and is reported to emerge in the cerebrospinal fluid (CSF). We evaluated the elimination of cimetidine from CSF by the method of ventriculo-cisternal perfusion in rats. The extraction ratio of cimetidine at the low perfusate concentration (14 nM) was 0.190 +/- 0.023 (n = 3), while that significantly (p less than 0.02) decreased to 0.0916 +/- 0.081 (n = 3) at the high concentration (4 mM). No significant difference was observed in the production rate of CSF between these two concentrations. These findings suggest that cimetidine is excreted from CSF to blood by a saturable transport system.

Saturable transport of cimetidine from cerebrospinal fluid to blood in rats.