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The developmental process from micelle to liquid crystal via the bilayer membrane is described based on electron microscopic observations using the freeze fracture method in solutions containing ursodeoxycholate, phosphatidylcholine and cholesterol. Comparisons of sodium tauroursodeoxycholate and sodium taurochenodeoxycholate solutions were performed and this developmental process was confirmed only in the sodium tauroursodeoxycholate, phosphatidylcholine and cholesterol solution under physiological conditions.

The developmental process from micelle to liquid crystal in the ursodeoxycholate, phosphatidylcholine and cholesterol solution.