English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was designed to determine whether ouabain could inhibit insulin-stimulated ion and/or glucose transport in rat ventricular slices. In the slices which were obtained by tearing with forceps from the inside surface of the ventricle, insulin (0.1-100 ng/ml, 20-min treatment) stimulated ATP hydrolysis (nmol inorganic phosphate/mg tissue/20 min) and 86Rb uptake (nmol Rb/mg tissue/8 min) in a concentration-dependent fashion by up to about 25%, compared with control experiment. About 10-fold higher concentrations of insulin stimulated glucose-[14C] uptake by the slices (nmol glucose/mg tissue/30 min). Both the stimulant effects of insulin on ion and glucose transport were inhibited by ouabain (0.1-1 mM, 20-min treatment) in a similar concentration-response relationship. It thus never appears that two or more independent transmembrane signals would be generated simultaneously in response to the insulin-receptor interaction to operate ion and glucose transport systems in rat cardiac muscle. In addition, rat ventricular slices were shown to provide a sensitive tool for the evaluation of insulin effects on ion transport systems in the muscle.

Ouabain-sensitive insulin stimulation of ion and glucose transport in rat ventricular slices.