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Effect of islet-activating protein (IAP) on glucose utilization of peripheral tissues and glycogen synthesis of the liver was investigated in diabetic KK mice. The 14C-content of diaphragm glycogen following the injection of [U-14C] glucose was much less in KK mice than in dd/Y mice, and it was restored to normal in KK mice treated with IAP. The enhanced glucose utilization in these mice was completely abolished by the injection of anti-insulin serum. Glycogen synthesis of the liver after glucose load was also less in KK mice than in dd/Y mice, and it was clearly suppressed in both groups of mice by IAP treatment. It was concluded that improved glucose tolerance of IAP-treated KK mice was mostly due to enhanced glucose utilization of peripheral tissues secondary to increased insulin secretion induced by IAP injection.

Enhanced peripheral glucose utilization and suppressed hepatic glycogen synthesis in KK mice treated with islet-activating protein (IAP).