English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effects of blended Chinese traditional medicines applied for diabetes mellitus were studied on the pattern of action to the glucose tolerance curves in genetically diabetic KK-CAy mice. The glucose tolerance curves of KK-CAy mice (humping curve) were analyzed pharmacokinetically by the mathematical model (COmpartment-H model). The curves could be classified into several types of pattern through the analysis for the humping effect. Daisaikoto-Ka-Jio and Byakko-Ka-Ninjinto reduced the humping effect, whereas Hachimigan had a tendency to enhance it. On the combined effect of crude drugs prescribed in the blended medicines, the effect of Daisaikoto was lessened by subtracting Rehmanniae Rhizoma from Daisaikoto-Ka-Jio and Byakkoto (subtracted Ginseng Radix from Byakko-Ka-Ninjinto) had no inhibitory effect on the humping. Rehmanniae Rhizoma or Ginseng Radix along had the similar effect on decreasing the humping. the hypoglycemic component of Ginseng Radix (DPG3-2) decreased the humping effect in a dose-dependent manner. In conclusion, the effects of crude drugs and the active component of the crude drug supported those of the blended medicines on the humping effect by utilizing the pharmacolinetical analysis.

The pattern of action of blended chinese traditional medicines to glucose tolerance curves in genetically diabetic KK-CAy mice.