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Male IVCS mice fed pellets containing 8 nmol methylmercuric chloride (MMC)/g feed for 32 days were additionally inhaled elemental mercury vapor (Hg0) or injected mercuric chloride (Hg2+). The modified distribution of accumulated organic mercury was observed 24 hr after exposure to inorganic mercurials. The body burden of organic mercury decreased significantly in MMC + Hg2+ treated mice and moderately (nor significant) in MMC + Hg0 treated mice when compared with MMC treated mice. In spite of the decreased body burden, the organic mercury levels in brain, kidneys and blood MMC + Hg0 treated mice, and in kidneys of MMC + Hg2+ treated mice were elevated. In bile, organic mercury concentration after Hg0 or Hg2+ exposure was reduced. The decrease of the blood cells-to-plasma ratio of organic mercury in mice after Hg0 exposure is in agreement with the data reported for workers exposed to mercury vapor.

Modified distribution of methylmercury by additional exposure to elemental mercury or mercuric chloride in mice fed methylmercuric chloride.