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Nine quinolone alkaloids (1-9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-kappa B-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC(50) values between 0.91 microM and 15.91 microM. Of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-kappa B activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.

Quinolone Alkaloids with Inhibitory Activity against Nuclear Factor of Activated T Cells from the Fruits of Evodia rutaecarpa