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Recently, we developed novel tumor necrosis factor (TNF)-alpha production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay.

Antiangiogenic Activity of Tumor Necrosis Factor-.ALPHA. Production Regulators Derived from Thalidomide.