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The reactivity of malondialdehyde(MDA) with spermidine at the physiological pH was considerably higher than that with putrescine, glycine, lysine, methylamine or dimethylamine, and the major reaction product of MDA-spermidine adduct was identified as N4-(2-propenal)spermidine.

Identification of N4-(2-Propenal)spermidine as a Major Reaction Product of Malondialdehyde and Spermidine.