English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  There are currently two widely used methods for preoperative localization of ductal carcinoma in situ (DCIS) of the breast: wire-guided localization (WGL) and radioactive seed localization (RSL). Several studies compared these localization techniques in small cohorts.    Objective  The aim of this study was to compare the surgical resection margin status between RSL and WGL in a large national cohort of patients with DCIS.    Patients and Methods  We included patients from the Dutch Pathology Registry who underwent breast-conserving surgery for DCIS by either RSL ( n  = 1851) or WGL ( n  = 2187) between 2009 and 2019. Several clinicopathological characteristics were compared between these two groups, including resection margin status and number of re-excisions.Results  Patients undergoing RSL were younger ( p  = 0.014) and were more often diagnosed with a large DCIS ( p  = 0.013), high grade DCIS ( p  < 0.001) and comedonecrosis ( p  < 0.001) compared with patients undergoing WGL. There was no significant difference in resection margin status between both groups ( p  = 0.089) and the number of re-excisions ( p  = 0.429). However, in case of re-excision, patients in the RSL group were more often treated with breast-conserving surgery ( p  = 0.029).    Conclusion  In this large national cohort study of patients with DCIS, we demonstrated that there was no difference in resection margin status between both procedures, or in the number of re-excisions, but patients in the RSL group were more often treated with breast-conserving therapy in case of a re-excision.

Radioactive Seed Versus Wire-Guided Localization for Ductal Carcinoma in Situ of the Breast: Comparable Resection Margins