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The oxidative biochemistry of living frog skin in so far as it is concerned with the maintenance of the electrical potential across the skin has been investigated by the use of the respiratory inhibitor iodoacetate. It appears that internal supplies of carbohydrate and external supplies of dl-lactate, pyruvate, acetate, propionate, n-butyrate, iso-butyrate and possibly crotonate can all be oxidized to precursors of the potential. This is not so for external supplies of formate, glycollate, succinate, acrylate, malonate, dl-β-hydroxybutyrate, and acetoacetate.

The Effect Of Iodoacetate On The Electrical Potential And On The Oxygen Uptake Of Frog Skin