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In a recent paper published in Development , Koide et al. provide evidence for a negative regulatory action of 7-dehydrocholesterol reductase (DCHR7) on the Hedgehog pathway ([Koide et al., 2006][1]). In a series of elegant experiments, the authors show that: (1) DHCR7 expression is intimately

A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?