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Methods are introduced and illustrated for synthesizing evidence from case-control and cohort studies, and controlled trials, accounting for differences among the studies in their design, length of follow-up and quality. The methods, based on hierarchical but nonexchangeable Bayesian models, are illustrated in a synthesis of disparate information about the health effects of passive exposure to environmental tobacco smoke.

Adjusted Likelihoods for Synthesizing Empirical Evidence from Studies that Differ in Quality and Design: Effects of Environmental Tobacco Smoke