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We consider the population genetics problem: how long does it take beforesome member of the population has $m$ specified mutations? The case $m=2$ isrelevant to onset of cancer due to the inactivation of both copies of a tumorsuppressor gene. Models for larger $m$ are needed for colon cancer and otherdiseases where a sequence of mutations leads to cells with uncontrolled growth.

A waiting time problem arising from the study of multi-stage carcinogenesis