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To determine whether memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer disease (AD) biomarkers, we examined associations between performance in 3 memory tasks and CSF β-amyloid (Aβ) 42 /Aβ 40 and phosopho-tau 181 (p-tau 181 ) in cognitively unimpaired older adults (CU).

Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease