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ence of comorbid depression in Alzheimer disease (AD) has been demonstrated to correspond to increases in AD-related neuropathologic changes beyond age, sex, level of education, and cognitive status. Moreover, lifetime history of depression in patients with AD has been associated with higher levels of plaque and tangle formation in the hippocampus. The authors did not provide information on the use of psychotropic agents such as antidepressants or lithium. Antidepressants or mood stabilizers may not only counteract depression, but also exert neuroprotective and neurotrophic actions extending beyond mood effects.

MS disease activity in RESTORE: A randomized 24-week natalizumab treatment interruption study