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Editors’ Note: Kezuka et al. report their experience with patients with neuromyelitis optica who were positive to both AQP4 antibodies and MOG antibodies, which seems to differ from the clinical profile reported by Sato et al. The latter wonder whether those findings are due to falsepositive results on ELISA testing. Kabai suggests that the self-reported alcohol consumption in the study on alcohol consumption and cognitive decline in early old age may be underestimated and hence the study findings may be biased. Sabia and Singh-Manoux respond. —Chafic Karam, MD, and Robert C. Griggs, MD

Distinction between MOG antibody–positive and AQP4 antibody–positive NMO spectrum disorders