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Theses results suggest that for individuals inheriting the IL6R C allele, the cytokine exerts a disease- and location-specific role in ALS. Follow-up, prospective studies are necessary, as this subgroup of patients may be identified as ideally responsive to IL6 receptor-blocking therapies.

IL6 receptor 358 Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis

IL6 receptor ³⁵⁸ Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis