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CD8 T cells were until now considered the central players in the immunopathogenesis of RE. Our study adds to previous findings and highlights that CD4 TCCs and γδ T cells that secrete IFN-γ and TNF are also involved. These findings underline the complexity of T-cell immunity in RE and suggest a specific role for CD4 T cells in orchestrating the CD8 T-cell effector immune response.

Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis