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In vivo detection of molecular hallmarks of neurodegenerative diseases will be a prerequisite to well-conducted therapeutic trials. Understanding the in vivo behavior of these PET biomarkers in the setting of various neurodegenerative processes is imperative to their proper use in such trials and for research studies focused on the basic neurobiology of neurodegeneration. This study supports the high specificity of neocortical F-AV-1451 binding to AD-like tau and the lack of PiB binding to PrP plaques. It is uncertain how early in the disease course tau pathology appears in the brains of individuals who carry this  gene mutation or how it evolves throughout the disease course, but future longitudinal F-AV-1451 imaging of symptomatic and asymptomatic individuals in this kindred will help address these uncertainties.

Amyloid- and tau-PET imaging in a familial prion kindred