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Editors’ Note: Is synthetic cannabis more likely than pure cannabis to be associated with stroke? McSherry raises an interesting question. Chamberlain points out that the glioma biomarker ATRX (a-thalassemia/mental retardation syndrome X-linked) gene was not mentioned in the study by Wick et al. on the value of methylguanine methyltransferase (MGMT) in gliomas. The authors respond and discuss the role of ATRX and its interaction with MGMT and IDH1 (isocitrate dehydrogenase 1). —Chafic Karam, MD, and Robert C. Griggs, MD

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation