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To validate the ability of candidate CSF biomarkers to distinguish between the 2 main forms of frontotemporal lobar degeneration (FTLD), FTLD with TAR DNA-binding protein 43 (TDP-43) inclusions (FTLD-TDP) and FTLD with Tau inclusions (FTLD-Tau).

Reduced CSF p-Tau 181 to Tau ratio is a biomarker for FTLD-TDP

Reduced CSF p-Tau ₁₈₁ to Tau ratio is a biomarker for FTLD-TDP