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Nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD), but observational studies and trials have offered contradictory results. Prior studies have also been relatively short and small. We examined the effects on AD risk of NSAID use for &gt;5 years and of NSAIDs that suppress formation of A beta (1-42) amyloid in a large health care database.

Protective effects of NSAIDs on the development of Alzheimer disease