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In the Videnovic et al. report on capecitabine-induced leukoencephalopathy, manifestations included nausea, confusion, short-term memory loss, headaches, vertigo, ataxia, dysarthria, and body shaking/stiffening. Distinctive multifocal MRI abnormalities including involvement of the splenium of the corpus callosum were present in all cases.see page 1792 Commentary by Lisa M. DeAngelis, MDNeurotoxicity is second only to myelosuppression as a cause of chemotherapy dose reduction or termination in patients under treatment for cancer. Capecitabine is an …

December 13 Highlight and Commentary: Capecitabine-induced multifocal leukoencephalopathy