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We previously found that variation in a quantitative trait locus, including the gene-encoding endothelin-converting enzyme 1 ( Ece1 ), accounted for 40% of the variance in bone biomechanics and bone mineral density (BMD) in an intercross of recombinant congenic mouse strains.

The −839(A/C) Polymorphism in the ECE1 Isoform b Promoter Associates With Osteoporosis and Fractures