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Diabetes is a chronic metabolic and inflammatory disorder resulting in long term vascular complications. Glucotoxicity has been proposed to aggravate inflammatory stress. In this background,effect of early insulin therapy on inflammatory markers in relation to the glycemic status could be relevant in the newly diagnosed Type 2DM patients. Clinical studies highlighting this pathophysiologic aspect are sparse. Objective: To determine the effect of early insulin therapy in newly diagnosed patients with type 2 diabetes mellitus on inflammatory markers and glucotoxicity. Methods: 40 newly diagnosed type 2 diabetes patients, attending the endocrinology OPD at a tertiary teaching hospital were enrolled in this treatment related follow up study after institutional ethical committee clearance, conducted between May 2019 to February 2020. Patients with HbA1C &amp;gt; 8.5% to &amp;lt;12.5% were included in the study. Metabolic (FPG, PPG, HbA1c), and inflammatory parameters (Serum IL-6, Serum TNF alpha levels) were assessed both at baseline and after 9 months of insulin treatment. A simple,conventional twice daily premixed insulin was initiated at a starting dose of insulin at 0.5 U/kg/day and the dose was titrated according to FPG and 2 hr PPG in order to maintain glycemic goals as per ADA standards. Results: The study included 40 subjects with a mean age of 43.9 years and a mean BMI of 26.46 kg/m2. At the end of 9 months of the study, mean FPG, PPG, HbA1C were significantly reduced [FPG (118.45± 24.74mg/dl), PPG (152± 25 mg/dl), HbA1c (6.67± 0.42%)] as compared to baseline [FPG, (218.4± 37.84mg/dl), PPG (307±62mg/dl), HbA1C (9.95± 1.39%) (p &amp;lt;0.001). A statistically significant decrease in inflammatory markers like IL6, TNF alpha, from baseline to 9 months [.IL6 5.365±1.465 to 2.819±0.697 pg/ml, S.TNF alpha 36.476±16.902 to 11.274±3.712 pg/ml.] (p &amp;lt;0.001) was observed. Correlation studies revealed at 9 months, a highly significant positive correlation between FPG, PPG and IL6 and TNF alpha levels (p&amp;lt;0 .001), in comparison with baseline (p&amp;lt; 0.05). However IL6 levels significantly correlated with HBA1c both at baseline and at 9 months (p&amp;lt;0.05), whereas only a non significant positive correlation with TNF alpha was observed. Conclusion: Early Insulin treatment has beneficial effect on both Inflammation and glucotoxicity in newly diagnosed Type2 DM. Effective, simple and early insulin regimen offers a pathophysiologic based therapeutic perspective aiming at improving the natural course of diabetes.

Study of the Effect of Early Insulin Therapy on Inflammation and Its Correlation With Glucotoxicity in Newly Diagnosed T2DM