English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

To examine the major immunogenic regions of the human TSH receptor (hTSHR), we examined 14 patients with Graves' disease and 14 healthy control subjects for their peripheral blood T cell proliferative responses to 29 synthetic peptides representing the entire ectodomain of the hTSHR (TSHR-ecd). By combining an analytical approach encompassing the grading of peptide-induced responses and nonparametric testing, we obtained evidence for highly significant differences (P = &lt; 0.1) in the patient group compared with minor differences in the control group (P = 0.045). To account for this difference, we identified four major T cell epitopes (amino acid 247-266, 202-221, 142-161, and 52-71), by multiple comparison analysis, in the patient group. Furthermore, we demonstrated by radiolabeled PCR that the responding T cells were clonally expanding. These findings demonstrate that despite likely differences in human leukocyte antigen type among patients with Graves' disease, several distinct hTSHR epitopes elicited significant responses in the immune system of patients with Graves' disease, and that such patients are most often poorly tolerant to particular epitopes of the TSH receptor ectodomain, The data support the notion of TSHR peptide antigens overriding human immune heterogeneity in patients with Graves' disease, and raise the possibility of applying analog peptide blockade to suppress T cell responsivity.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Detection of Major T Cell Epitopes on Human Thyroid Stimulating Hormone Receptor by Overriding Immune Heterogeneity in Patients with Graves’ Disease<sup>1</sup>

Detection of Major T Cell Epitopes on Human Thyroid Stimulating Hormone Receptor by Overriding Immune Heterogeneity in Patients with Graves’ Disease1

Detection of Major T Cell Epitopes on Human Thyroid Stimulating Hormone Receptor by Overriding Immune Heterogeneity in Patients with Graves’ Disease¹