Open AccessA Lower Maternal Cortisol-to-Cortisone Ratio Precedes Clinical Diagnosis of Preterm and Term Preeclampsia by Many Weeks
Author(s) -
Nimesh Jayasuriya,
Alice E. Hughes,
Ulla Sovio,
Emma Cook,
D. Stephen CharnockJones,
Gordon C. S. Smith
Publication year - 2019
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2018-02312
Subject(s) - cortisone , medicine , preeclampsia , pregnancy , endocrinology , gestational age , logistic regression , fetus , obstetrics , biology , genetics
Previous studies have shown reduced placental levels of 11-β-hydroxysteroid dehydrogenase type 2 (11βHSD2) in preeclampsia (PE). However, it is unknown if the maternal cortisol-to-cortisone ratio is predictive of placental complications of pregnancy.
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