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Apparent mineralocorticoid excess (AME) is a rare autosomal recessive disease resulting from mutations within the hydroxysteroid (11β-dehydrogenase2 [HSD11B2]) gene causing a prominent mineralocorticoid receptor activation by cortisol and hypokalemic low renin hypertension as the main clinical feature.

Apparent Mineralocorticoid Excess by a Novel Mutation and Epigenetic Modulation byHSD11B2Promoter Methylation