Open AccessSyntaxin 4 Up-Regulation Increases Efficiency of Insulin Release in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus
Author(s) -
Eunjin Oh,
Natalie D. Stull,
Raghavendra G. Mirmira,
Debbie C. Thurmond
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2221
Subject(s) - islet , endocrinology , medicine , syntaxin , insulin , pancreatic islets , type 2 diabetes , diabetes mellitus , biology , secretion , insulin oscillation , exocytosis
Evidence suggests that dysfunctional β-cell insulin release precedes type 1 and type 2 diabetes (T1D and T2D, respectively) and that enhancing the efficiency of insulin release from pancreatic islet β-cells may delay/prevent these diseases. We took advantage of the rare opportunity to test this paradigm using islets from human type 2 diabetic individuals.
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